INDICATIONS AND USAGE
Esmolol Hydrochloride is a beta-adrenergic blocker used for the short-term treatment of:
- Control of ventricular rate in supraventricular tachycardia including atrial fibrillation and atrial flutter and control of heart rate in noncompensatory sinus tachycardia
- Control of perioperative tachycardia and hypertension
IMPORTANT SAFETY INFORMATION
CONTRAINDICATED IN: severe sinus bradycardia; heart block greater than first degree; sick sinus syndrome; decompensated heart failure; cardiogenic shock; coadministration of IV cardiodepressant calcium-channel antagonists (e.g. verapamil) in close proximity to esmolol; pulmonary hypertension; known hypersensitivity to esmolol.
WARNINGS AND PRECAUTIONS
RISK OF: hypotension, bradycardia, cardiac failure; exacerbating reactive airway disease; unopposed alpha-agonism and severe hypertension in untreated pheochromocytoma; myocardial ischemia when abruptly discontinued in patients with coronary artery disease. In diabetes mellitus, increases the effect of hypoglycemic agents and masks hypoglycemic tachycardia. The most common adverse reactions (incidence >10%) are symptomatic and asymptomatic hypotension. Drug interactions may occur with digitalis glycosides, anticholinesterases, antihypertensive agents, sympathomimetic drugs, and vasoconstrictive and positive inotropic effect substances.
Please see the package insert for complete prescribing information.
*BREVIBLOC® is a registered trademark of Baxter International Inc., or it’s subsidiaries.
References
1. Esmolol Hydrochloride in Water for Injection [prescribing information]. WG Critical Care, LLC; Paramus, NJ. April 2016. 2. Brevibloc (esmolol hydrochloride) [prescribing information]. Baxter Healthcare Corporation; Deerfield, IL. April 2014. 3. AHFS Drug Information 2018. 1st edition. ASHP; Bethesda, MD. 4. Trissel LA. Handbook on Injectable Drugs. 16th edition. ASHP; Bethesda, MD. 5. Gahart Bl, Nazareno AR. Gahart’s 2018 Intravenous Medications: A Handbook for Nurses and Health Professionals. 34th edition. Mosby; St. Louis, MO.
Esmolol HCl in WFI Contains the Same Active Ingredient As Brevibloc (esmolol HCl) Injection*, Without Sodium Chloride
Esmolol HCl in WFI Has Similar Product Characteristics to Brevibloc1-2
References
1. Esmolol Hydrochloride in Water for Injection [prescribing information]. WG Critical Care, LLC; Paramus, NJ. April 2016. 2. Brevibloc (esmolol hydrochloride) [prescribing information]. Baxter Healthcare Corporation; Deerfield, IL. April 2014. 3. AHFS Drug Information 2018. 1st edition. ASHP; Bethesda, MD. 4. Trissel LA. Handbook on Injectable Drugs. 16th edition. ASHP; Bethesda, MD. 5. Gahart Bl, Nazareno AR. Gahart’s 2018 Intravenous Medications: A Handbook for Nurses and Health Professionals. 34th edition. Mosby; St. Louis, MO.
Osmolarity/Osmolality of WGCC Esmolol HCl in WFI Is In Range of Other Commonly Used Products3
*Represented as osmolality (mOsmol/L)
†Represented as osmolarity (mOsm/L)
References
1. Esmolol Hydrochloride in Water for Injection [prescribing information]. WG Critical Care, LLC; Paramus, NJ. April 2016. 2. Brevibloc (esmolol hydrochloride) [prescribing information]. Baxter Healthcare Corporation; Deerfield, IL. April 2014. 3. AHFS Drug Information 2018. 1st edition. ASHP; Bethesda, MD. 4. Trissel LA. Handbook on Injectable Drugs. 16th edition. ASHP; Bethesda, MD. 5. Gahart Bl, Nazareno AR. Gahart’s 2018 Intravenous Medications: A Handbook for Nurses and Health Professionals. 34th edition. Mosby; St. Louis, MO.
Esmolol HCl in WFI Has Unique Attributes vs Brevibloc1-2
Esmolol HCl in WFI Is a Clear Choice For STAT Dosing
- Ready-to-use in a clear bag when removed from overwrap for immediate dosing
- Clear bag allows immediate visual inspection for particulate matter
References
1. Esmolol Hydrochloride in Water for Injection [prescribing information]. WG Critical Care, LLC; Paramus, NJ. April 2016. 2. Brevibloc (esmolol hydrochloride) [prescribing information]. Baxter Healthcare Corporation; Deerfield, IL. April 2014. 3. AHFS Drug Information 2018. 1st edition. ASHP; Bethesda, MD. 4. Trissel LA. Handbook on Injectable Drugs. 16th edition. ASHP; Bethesda, MD. 5. Gahart Bl, Nazareno AR. Gahart’s 2018 Intravenous Medications: A Handbook for Nurses and Health Professionals. 34th edition. Mosby; St. Louis, MO.
